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Generic Augmentin, a combination of Amoxicillin and Clavulanate Potassium, is a trusted broad-spectrum antibiotic used to treat various bacterial infections. Amoxicillin/clavulanate potassium is a prescription antibacterial medication approved by the U.S. Food and Drug Administration (FDA) for the treatment of certain bacterial infections. These include lower respiratory tract infections, such as community-acquired pneumonia, ear and sinus infections, skin infections, and urinary tract infections. Community-acquired pneumonia, a bacterial respiratory disease, can also occur as an opportunistic infection (OI) in individuals with HIV. Opportunistic infections are conditions that occur more frequently or present more severely in people with weakened immune systems—such as those living with HIV—compared to individuals with healthy immune systems. It effectively combats respiratory tract infections, skin and soft tissue infections, urinary tract infections, and more. The addition of clavulanate enhances its efficacy against beta-lactamase-producing bacteria, ensuring reliable treatment.
Active Ingredients: Amoxicillin/Clavulanate
Dosage Forms: Tablets
Available Strengths: 250/125 mg, 500/125 mg, 750/250 mg, 875/125 mg
AUGMENTIN extended-release tablets, 1 g (base equivalent to 62.5 mg), are the subject of NDA 050785, owned by US Antibiotics, LLC, and initially approved on September 25, 2002.
Indications: Augmentin XR is indicated for the treatment of adults and pediatric patients with:
Additionally, it is effective against S. pneumoniae with reduced penicillin sensitivity, defined as a minimum inhibitory concentration of penicillin equivalent to 2 µg/mL.
Price: From 1.70 USD per tablet
Availability: In Stock
Generic Augmentin should be taken at the start of a meal to reduce gastrointestinal side effects and optimize absorption. It is safe for use in adults and children over 40 kg. Consult your healthcare provider for proper dosage based on your medical condition.
Common side effects include mild diarrhea, nausea, and skin rash. Severe allergic reactions are rare but require immediate medical attention.
Experience fast relief from bacterial infections with Generic Augmentin. Order online today and enjoy quick delivery across the USA with free consultations from our licensed specialists.
When dangerous bacteria enter the body and proliferate, it can lead to bacterial infections, which can result in infection of the respiratory tract, sinusitis, otitis media, skin infections, and urinary tract infections. Depending on the location afflicted, these infections may present with fever, inflammation, exhaustion, and localized pain. Microorganisms with only one cell, bacteria are among the first known life forms on Earth. Microorganisms come in millions of varieties and can be found in almost any location on the planet. They are present deep within the earth's outermost layer as well as in soil and ocean. Even radioactive waste can support certain bacteria. Humans as well as livestock have a lot of bacteria that live on their skin, in their mouths, in their respiratory systems, in their digestive systems, and in their vomit and genital tracts without doing any harm. Residents refer to these bacteria as the "microbiota." The microbiota of the human body has at least as many bacteria as human cells. Many of these bacteria are good for you; they help with digestion or stop the growth of bad bacteria. Disease is triggered by a very small number of bacterial species. The term "pathogenic bacteria" describes these. In specific scenarios, the local flora may also function as a pathogen and cause disease under particular circumstances. Through the production of toxic chemicals, tissue invasion, or a combination of the two, bacteria can cause disease. Inflammation brought on by particular organisms can impact the kidneys, gastrointestinal tract, heart, lungs, brain system, and more. Certain bacteria, like Helicobacter pylori, are bacteria that may potentially raise the chance of getting cancer.
| Infection Type | Symptoms | Potential Complications |
|---|---|---|
| Respiratory Tract Infections | Cough, fever, shortness of breath | Pneumonia, bronchitis |
| Sinusitis | Facial pain, nasal congestion | Chronic sinusitis |
| Otitis Media | Ear pain, hearing difficulties | Hearing loss, eardrum perforation |
| Skin Infections | Redness, swelling, warmth | Abscess formation, cellulitis |
| Urinary Tract Infections (UTIs) | Burning during urination, frequent urge | Kidney infections |
Amoxicillin is a semi-synthetic antibiotic that first came to the attention of the medical community due to its broad spectrum of activity. It is effective against a variety of Gram-positive and Gram-negative bacteria, making it one of the most popular drugs in the treatment of various infections. A study published in the journal Clinical Infectious Diseases (2018) confirmed the high efficacy of amoxicillin in treating conditions such as pneumonia, otitis media, and urinary tract infections. However, as is often the case in the world of medicine, there are two sides to every coin. Despite its power, amoxicillin faces a major obstacle: its ability to fight bacteria can be neutralized by enzymes called beta-lactamases. These enzymes break down the structure of amoxicillin, making it ineffective against a number of microorganisms. According to a 2019 study published in the journal Antimicrobial Agents and Chemotherapy , about 30% of Staphylococcus aureus strains produce beta-lactamases, which significantly reduces the effectiveness of amoxicillin. Thus, although amoxicillin is an excellent choice for the treatment of many diseases, it cannot always cope with the more “stubborn” strains of bacteria. This limitation emphasizes the importance of finding solutions that can improve the effectiveness of this antibiotic. And this is where clavulanic acid comes to the rescue.
Clavulanic acid is a special compound that plays the role of a beta-lactamase inhibitor. Literally, it “disarms” those enzymes that can destroy amoxicillin. Its action can be compared to a defender, which stands guard over the antibiotic and does not allow it to lose its properties. Clavulanic acid has an amazing ability to bind and inactivate different types of beta-lactamases, especially those produced by microorganisms resistant to penicillins and cephalosporins. We identified five surgical studies using the suture method and 22 surgical studies using mesh. The surgical studies using the suture method were of very low methodological quality. The surgical studies using mesh had low to medium methodological quality. This review shows that antibiotics do not prevent the occurrence of any wound infections after suture-assisted hernia surgery. For mesh hernia surgery in low-risk wound infection settings, antibiotics probably have little or no effect on preventing postoperative superficial wound infections. However, in high-risk infection settings, it is unclear whether antibiotics reduce the risk of superficial wound infection. For deep wound infections, we show that antibiotics probably have little or no effect on risk reduction in both low- and high-risk infection settings. A study conducted by a team of scientists from Johns Hopkins University and published in the Journal of Antimicrobial Chemotherapy (2020) showed that the combination of amoxicillin with clavulanic acid significantly increases the effectiveness of treatment of infections caused by bacteria producing beta-lactamases. In particular, this combination was found to provide successful treatment in 85% of cases of infections caused by Escherichia coli compared to 45% with amoxicillin alone. However, as with any drug, clavulanic acid has its limitations. It is most effective against plasmid beta-lactamases, which are transmitted between bacteria through so-called “transfer” elements (plasmids). This makes it a particularly valuable tool in the fight against rapidly spreading forms of antibiotic resistance. But when it comes to chromosomal type 1 beta-lactamases, clavulanic acid is less effective. A study published in Nature Microbiology (2021) found that clavulanic acid was only 30% effective against these types of beta-lactamases, indicating the need for further developments in this area.
The inclusion of clavulanic acid in Augmentin protects amoxicillin from degradation by beta-lactamases and significantly broadens its antibacterial spectrum. This combination makes Augmentin effective against microorganisms that are typically resistant to other penicillins and cephalosporins.
By offering both broad-spectrum bactericidal activity and beta-lactamase inhibition, Augmentin is a powerful treatment option. It is particularly effective against a variety of gram-positive and gram-negative bacteria, addressing infections caused by otherwise resistant pathogens.
This dual-action mechanism makes Augmentin an essential antibiotic for treating infections where resistance to standard penicillins or cephalosporins is a concern.
Augmentin combines two active ingredients to combat bacterial infections effectively:
This dual-action mechanism allows Augmentin to treat infections caused by bacteria that are resistant to conventional antibiotics.
| Benefit | Description |
|---|---|
| Broad-Spectrum Action | Effective against a wide range of bacterial infections |
| Resistance Management | Overcomes bacterial resistance through Clavulanate |
| Convenient Dosage Forms | Available in tablets, chewables, and suspensions for all ages |
| Rapid Relief | Reduces symptoms quickly, restoring daily activities |
Before starting Augmentin, inform your doctor about any allergies, liver or kidney conditions, or other medications you are taking to avoid adverse interactions. Very low-quality evidence indicates that it is uncertain whether antibiotics reduce the risk of postoperative wound infections after suture-assisted hernia surgery. Medium-quality evidence suggests that antibiotics probably have little or no effect on preventing superficial or deep wound infections after hernia surgery with mesh in low-risk infection settings. Evidence of (very) low quality shows that it is uncertain whether antibiotics reduce the risk of superficial wound infections, and antibiotics have little or no effect on the development of deep wound infections after mesh-assisted hernia surgery in high-risk infection settings. Pregnant and breastfeeding individuals should consult a healthcare provider before use.
Augmentin is a combination antibiotic containing Amoxicillin, a penicillin-type antibiotic, and Clavulanate, a beta-lactamase inhibitor. This combination enhances the effectiveness of Amoxicillin by preventing bacteria from breaking it down, making it effective against a broader range of infections.
Augmentin is used to treat various bacterial infections, including respiratory tract infections, sinusitis, ear infections, urinary tract infections, and skin infections. It is also prescribed for dental infections and some gastrointestinal infections caused by susceptible bacteria.
Augmentin should be taken exactly as prescribed by your doctor. It is usually taken with food to reduce the risk of stomach upset. The dosing schedule may vary depending on the severity and type of infection. Always complete the full course of treatment, even if you feel better before finishing it.
Common side effects include mild diarrhea, nausea, and skin rash. Serious side effects, though rare, may include severe diarrhea, allergic reactions, or liver problems. Contact your doctor if you experience any unusual or severe symptoms.
Yes, Augmentin can interact with certain medications, such as anticoagulants (e.g., warfarin), allopurinol, and oral contraceptives. Always inform your doctor about any other medications or supplements you are taking to avoid potential interactions.
Before taking Augmentin, inform your doctor if you have any history of allergies, liver or kidney problems, or if you are pregnant or breastfeeding. Avoid missing doses and follow the prescribed regimen to ensure the infection is effectively treated.
Yes, free delivery options are available for Augmentin purchases in select regions. Please check the shipping details on the product page or contact customer support for more information.
Absolutely! We offer free online consultations with qualified healthcare professionals. Our doctors can help determine if Augmentin is suitable for your condition and provide guidance on its proper use. Schedule your consultation today for personalized advice.
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for the missed one.
January 11, 2025
Recent findings from the Journal of Pediatric Gastroenterology and Nutrition, published by researchers at Nationwide Children's Hospital, suggest that the widely prescribed antibiotic Amoxicillin-Clavulanate (commonly known as Augmentin) may offer new benefits beyond its traditional role in infection control. The study demonstrates that this medication can significantly enhance small intestine motility in children suffering from gastrointestinal motility disorders.
**Current Challenges in Pediatric GI Treatment**: Upper gastrointestinal (GI) symptoms such as nausea, vomiting, abdominal pain, early satiety, and bloating are common in children but remain difficult to manage due to a lack of effective therapeutic options. According to Dr. Carlo Di Lorenzo, Chief of Gastroenterology, Hepatology, and Nutrition at Nationwide Children’s Hospital, many existing treatments are either ineffective, poorly tolerated, or limited in scope. This creates an urgent need for innovative solutions, particularly for conditions affecting the small intestine.
**Key Findings from the Study**: The study involved 20 pediatric patients undergoing antroduodenal manometry. Researchers monitored their intestinal activity under fasting conditions for three hours, followed by a single dose of Amoxicillin-Clavulanate, administered either one hour before or one hour after a meal. The results showed that Amoxicillin-Clavulanate triggered migrating motor complexes in the small intestine similar to Phase III duodenal contractions observed during interdigestive motility. This effect occurred within 10–20 minutes of administration and was most pronounced when the medication was taken before meals.
**Potential Benefits for GI Health**: The induction of Phase III duodenal motility by Amoxicillin-Clavulanate offers several potential advantages: - **Enhanced intestinal transit**: Improved motility may help prevent bacterial overgrowth in the small intestine. - **Microbiome modulation**: Accelerated transit could positively impact gut microbiota, reducing complications associated with dysbiosis. - **Targeted support for severe cases**: The antibiotic shows promise in managing chronic pseudo-obstruction and motility disorders in patients relying on enteral feeding tubes.
**Safety and Risks**: While the findings are promising, Dr. Di Lorenzo cautions against widespread use of Amoxicillin-Clavulanate as a prokinetic agent due to potential risks, including: - Development of bacterial resistance, particularly among gram-negative species such as E. coli and Klebsiella. - Increased risk of Clostridium difficile-associated colitis. - Unclear mechanisms of action in its role as a motility agent, requiring further investigation.
**Future Directions**: Dr. Di Lorenzo emphasizes the importance of continued research to explore the long-term efficacy and safety of Amoxicillin-Clavulanate in GI motility disorders. He notes that in severe cases where other interventions have failed, the use of this antibiotic could be justified as a last-resort treatment. The study provides a foundation for future trials aimed at refining dosing strategies, minimizing risks, and identifying the patient populations most likely to benefit from this innovative approach.
This breakthrough offers renewed hope for children and their families grappling with the challenges of gastrointestinal disorders. By expanding our understanding of Amoxicillin-Clavulanate's therapeutic potential, healthcare providers may be able to better address the unmet needs of this vulnerable population.
Name: Jessica T.
Age: 34
I was prescribed Augmentin for a sinus infection that wouldn’t go away. After two doses, I started feeling less congested, but by day three, the nausea and diarrhea kicked in. I stuck it out because I wanted to get better, but it wasn’t easy. The medication worked, but I’d recommend taking it with food and maybe a probiotic to avoid the worst side effects.
Rating: 4 / 5
Name: Mark H.
Age: 45
I had a tooth abscess, and my dentist prescribed Augmentin. The infection cleared up within a few days, but I experienced intense stomach cramps and bloating. Taking it with a full meal helped a bit, but I was counting down the days to finish the course. It works, but I’d avoid it if you’re sensitive to antibiotics.
Rating: 3.5 / 5
Name: Laura W.
Age: 51
I’ve taken Augmentin a few times for different infections. It always works like a charm, but the side effects can be tough. This time, I had mild diarrhea and a metallic taste in my mouth. I still recommend it because it’s effective, but be prepared for some discomfort.
Rating: 4.3 / 5
Name: Michael S.
Age: 39
Augmentin cleared up my bronchitis in no time, but the side effects made it a mixed experience. By day four, I had severe bloating and felt fatigued all the time. The medicine did its job, but I’d consider asking for an alternative next time.
Rating: 3.8 / 5
Name: Emily R.
Age: 29
I was prescribed Augmentin for a skin infection. It worked fast—the redness and swelling went down in just two days. However, I experienced some nausea and dizziness. Drinking plenty of water and eating before taking it helped a lot. Overall, I’d take it again if I had to.
Rating: 4.5 / 5
Name: David L.
Age: 64
I’ve used Augmentin several times for sinus infections, and it’s always effective. This time, I had mild diarrhea and a headache for the first couple of days, but it was manageable. It’s one of the few antibiotics I trust to clear up tough infections.
Rating: 4.7 / 5
Name: Sophia M.
Age: 42
I had a severe ear infection, and Augmentin was prescribed. It worked quickly, but the side effects hit me hard—nausea, stomach cramps, and dizziness. It’s not a pleasant experience, but it got the job done. I’d recommend taking it with food to minimize discomfort.
Rating: 4 / 5
Name: John P.
Age: 53
I was skeptical about Augmentin because I’d heard about the side effects, but it worked wonders for my chest infection. I did experience some fatigue and a bit of gas, but it was worth it for how quickly I recovered.
Rating: 4.2 / 5
Name: Rachel B.
Age: 38
Augmentin cleared my sinus infection, but the side effects were tough. I had stomach pain and diarrhea for most of the course. I’d only use it again if nothing else worked because the discomfort was hard to deal with.
Rating: 3.5 / 5
Name: Linda S.
Age: 47
After a bad sinus infection, I was given Augmentin. The results were quick, but the side effects were almost unbearable. I had bloating, dizziness, and headaches. It worked, but I don’t think I’d choose this antibiotic again unless necessary.
Rating: 3 / 5
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